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Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal SignetRing Cell Carcinoma Article

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Engineering 2020, Volume 6, Issue 9,   Pages 1028-1034 doi: 10.1016/j.eng.2020.06.007

Abstract:

Gastric signet ring cell carcinoma (SRCC) and colorectal SRCC are the most aggressive histologicaltypes of carcinoma related to a poor prognosis, and place a heavy burden on public health.

Keywords： SEER Program     Survival analysis     Signet ring cell carcinoma     Metastases     Colorectal cancer     Gastric cancer    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: Nasopharyngeal carcinoma (NPC) is a malignant tumor that mainly occurs in East and Southeast Asia.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro anddownstream target of RFC4, and the overexpression of HOXA10 attenuated the silencing of RFC4-induced cellproliferation, colony formation inhibition, and cell cycle arrest.For the first time, this study reveals that RFC4 is required for NPC cell proliferation and may play

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCALDOB inhibited CtBP2-mediated repression of multiple cell cycle inhibitor, proapoptotic, and epithelial

Keywords： ALDOB     kidney cancer     cell proliferation    

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p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 412-418 doi: 10.1007/s11684-010-0260-x

Abstract: mutations have been found in many esophageal squamous cell carcinoma (ESCC) clinical specimens and cellidentified the correlation between p53 functional activation and its genotype in five different ESCC cellTo examine the potential p53 activation in a certain ESCC cell line, DNA damage methods including X-rayinvestigated using Western blot and reverse transcription-polymerase chain reaction (RT-PCR) after cellThe results showed that in KYSE 30 cell line with mutant and KYSE 150 with wild-type , p53 could be

Keywords： p53     esophageal squamous cell carcinoma     DNA damage    

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Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 384-387 doi: 10.1007/s11684-015-0405-z

Abstract:

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer

Keywords： carcinoma     small cell     urinary bladder neoplasms     diagnosis    

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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitional cellcarcinoma of bladder (BTCC) and normal epithelia of bladder was investigated, and the relationship between

Keywords： transitional cell carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the leading causes of cancer death worldwide.inhibiting CDK2 activity and affecting downstream phosphorylation of MCM2, c-Myc and Rb, resulting in cell

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral squamous cellcarcinoma (OSCC) and tongue cancer cell line Tca8113, as well as their effects on each other.

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-1029-3

Abstract: Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Keywords： tumor prognosis molecular     Microbiome subsets determine     center analysis microbiome     transcriptome data    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract:

Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leadingthe liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-basedpaper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-basedCritical issues that require consideration for the successful clinical translation of NK cell-based therapiesIf appropriately used and further optimized, NK cell-based therapies could dominate important roles in

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: Treating patients with esophageal squamous cell carcinoma (ESCC) is challenging due to the high chemoresistanceGDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylation

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 401-410 doi: 10.1007/s11684-013-0286-y

Abstract:

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers

Keywords： esophageal squamous cell carcinoma (ESCC)     early detection     molecular classification     molecular markers    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 478-486 doi: 10.1007/s11684-015-0420-0

Abstract: length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cellcarcinoma (ESCC) was still uncertain.

Keywords： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association    

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Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 242-254 doi: 10.1007/s11684-013-0256-4

Abstract: efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma

Keywords： hepatocellular carcinoma     hepatitis     cytokine     stem cell     miRNA    

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MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergisticeffects on cell motility

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 331-343 doi: 10.1007/s11684-015-0409-8

Abstract: validation revealed that miR-142-3p and miR-142-5p were significantly downregulated in hepatocellular carcinomaThe ectopic expression of miR-142 significantly reduced HCC cell migration and invasion.Overexpression of either miR-142-3p or miR-142-5p suppressed HCC cell migration, and overexpression ofregulate cell movement. miR-142-3p and miR-142-5p, which are mature miRNAs derived from the 3′showed a strong association of the putative gene targets of miR-142-3p and miR-142-5p with several cell

Keywords： hepatocellular carcinoma     microRNA     metastasis     cytoskeletal reorganization    

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Title Author Date Type Operation

Clinical Correlates and Prognostic Value of Different Metastatic Sites in Gastric and Colorectal SignetRing Cell Carcinoma

Jingjing Wu, Daiqiong Fang, Da Man, Wenrui Wu, Qing Wang, Yating Li, Jianzhong Ye, Lanjuan Li

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article

p53 functional activation is independent of its genotype in five esophageal squamous cell carcinoma cell

Junfang JI, Kun WU, Min WU, Qimin ZHAN,

Journal Article

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

Wanqiu Huang,Yang Luan,Lu Jin,Tao Wang,Ruibao Chen,Zheng Liu,Zhiqiang Chen,Ruzhu Lan

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Microbiome subsets determine tumor prognosis and molecular characteristics of clear-cell renal cell carcinoma

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cellcarcinoma

Journal Article

Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Li Shang, Mingrong Wang

Journal Article

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-control

Jiangbo Du,Wenjie Xue,Yong Ji,Xun Zhu,Yayun Gu,Meng Zhu,Cheng Wang,Yong Gao,Juncheng Dai,Hongxia Ma,Yue Jiang,Jiaping Chen,Zhibin Hu,Guangfu Jin,Hongbing Shen

Journal Article

Inflammation and liver tumorigenesis

Beicheng Sun, Michael Karin

Journal Article

MicroRNA-142-3p and microRNA-142-5p are downregulated in hepatocellular carcinoma and exhibit synergisticeffects on cell motility

Felice Ho-Ching Tsang,Sandy Leung-Kuen Au,Lai Wei,Dorothy Ngo-Yin Fan,Joyce Man-Fong Lee,Carmen Chak-Lui Wong,Irene Oi-Lin Ng,Chun-Ming Wong

Journal Article